The New England Patriots will have a tough opening day assignment in NFL betting as they host the defending AFC Central Division champion Cincinnati Bengals on September 12th to begin the 2010 NFL schedule. They will then travel to last year’s AFC runner up and AFC East Division rival New York to face the Jets on September 19th. That will be followed up by two more division games beginning at home against the Buffalo Bills on September 26th followed by an October 4th game for Monday night football at the Miami Dolphins. Online sportsbooks have the Patriots +850 in Super Bowl 2011 odds to win the championship, -115 favorites to win the AFC East and an over/under regular season win total of 8.5 UNDER (-140).

New England gets an early week 5 bye on the NFL schedule before getting back into action at home against the Baltimore Ravens on October 17th in a playoff revenge match from last year in which New England was dominated. New England will travel to AFC West champ the San Diego Chargers on October 24th and then draw the Minnesota Vikings at home on Halloween. That will be followed by a November 7th game at Cleveland on the NFL schedule and then a highly attractive Sunday night game at the Pittsburgh Steelers on November 14th, which will be a big draw at online sportsbooks.

New England will host the Indianapolis Colts on November 21st in a match-up of the two most dominant teams in NFL odds for well over a decade. That is followed with a Thanksgiving Day game vs the Detroit Lions on November 25th. On December 6th the Pats host the Jets in what could be an AFC East Division title match for Monday Night Football. The final quarter of the Patriots 2010 NFL schedule starts with two tough games beginning at the Chicago Bears on December 12th and then at home against the Green Bay Packers on December 19th. The Pats will wrap up the schedule with division games at Buffalo the day after Christmas and then at home against Miami on January 2nd.